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Br J Ophthalmol 1993;77:693-697 doi:10.1136/bjo.77.11.693
  • Research Article

Effects of topical mitomycin C on primary trabeculectomies and combined procedures.

  1. V P Costa,
  2. M R Moster,
  3. R P Wilson,
  4. C M Schmidt,
  5. S Gandham and
  6. M Smith
  1. Wills Eye Hospital, Jeffereson Medical College, Philadelphia, PA 19107.

      Abstract

      The charts were reviewed of all patients who underwent primary trabeculectomies (group 1) or combined procedures (phacoemulsification + intraocular lens implantation + trabeculectomy--group 2) and received intraoperative mitomycin C (0.4 mg/ml) between 1991 and 1992 at Wills Eye Hospital. A total of 54 eyes of 54 patients were included: 39 in group 1 and 15 in group 2. Intraocular pressure was controlled successfully in 97.4% of eyes in group 1 (mean follow up 6.7 months), and in 93.3% in group 2 (mean follow up 6.8 months). Main complications included choroidal detachment (n = 15), shallow anterior chamber (n = 9), cataract formation (n = 8), and hypotony maculopathy (n = 3). The use of mitomycin C in primary trabeculectomies and combined procedures is associated with high success rates. However, it may be associated with unacceptable risks of vision threatening complications related to excessive filtration.

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