rss
Br J Ophthalmol 1996;80:82-84 doi:10.1136/bjo.80.1.82
  • Research Article

Optic nerve vasomotor effects of topical apraclonidine hydrochloride.

  1. S Orgül,
  2. D R Bacon,
  3. E M Van Buskirk and
  4. G A Cioffi
  1. Devers Eye Institute, Legacy Portland Hospitals, Oregon, USA.

      Abstract

      AIMS: To examine, in vivo, the anterior optic nerve vasomotor effects of chronic apraclonidine hydrochloride in rabbits. METHODS: After local treatment in one randomly chosen eye with apraclonidine hydrochloride 0.5% over 21 days, the microvasculature of the optic nerve was examined in five rabbits using an intraluminal microvascular corrosion casting technique. The investigators were masked as to which eye was treated. The vasoconstriction near the branching point of arterioles supplying the optic nerve was calculated as a percentage of the downstream vessel calibre. An average constriction was calculated and compared between the treated and the contralateral, untreated, eyes by means of a two tailed t test for paired variables. Constriction values of a total of 72 arterioles supplying the optic nerve were obtained for the five rabbits. RESULTS: The average constriction in the treated and the control eyes was comparable (p = 0.96). CONCLUSION: Chronic administration of apraclonidine hydrochloride 0.5% produces no observable optic nerve vasomotor effects in the rabbit eye.

      This Article

      1. Abstract
      2. PDF

      Responses

      1. Submit a response
      2. No responses published

      Social bookmarking

      Register for free content


      Free sample
       This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
      View free sample issue >>

      Free archive
      The full back archive is now available for BJO. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006, back to volume 1 issue 1.
      Register to access the free archive >>

      Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.