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Br J Ophthalmol 81:877-883 doi:10.1136/bjo.81.10.877
  • Original Article
    • Clinical science

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment

Table 7

Bleb related infection after trabeculectomy with or without antiproliferatives

Author Year Antiproliferatives No of cases No of eyes Incidence (%)
Freedman 1978 none  2  133 1.5
Mills 1981 none  2  435 0.45
Shirato 1982 none  1  113 0.9
Katz 1985 none  2 1100 0.2
Wolner 1991 5-FU 13  229 5.7
 4†  133 3.0
 9‡   96 9.4
Ticho 1993 5-FU  4  105 3.8
 2†   88 2.3
 2‡   17 11.8
Higginbotham 1996 MMC  6  229 2.6
 2†  179 1.1
 4‡   50 8.0
Greenfield 1996 MMC 13  609 2.1
Present study 1997 none  1   76 1.3
 1†   74 1.4
 0‡    2 0
5-FU  3  228 1.3
 3†  210 1.4
 0‡   18 0
MMC  7  662 1.1
 5†  612 0.8
 2‡   50 4.0

  • ↵Number of trabeculectomies; †superiorly located blebs;‡inferiorly located blebs; 5-FU = 5-fluorouracil; MMC = mitomycin C.

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