rss
Br J Ophthalmol 81:1093-1098 doi:10.1136/bjo.81.12.1093
  • Original Article
    • Laboratory science

Endotoxins modulate the autocrine function of organ cultured donor corneas and increase the incidence of endothelial cell death

Table 2

Endothelial cell numerical densities and losses incurred (Δ) by six (I to VI) fellow pairs (left and right) of donor corneas after an initial 10 day equilibration phase and a subsequent experimental one, the onset of which was distinguished by change of medium and spiking of right corneal cultures with 25 000 units/ml of E coli endotoxin; left corneal cultures served as controls

Cell density (mm2)
Corneal pair no Before organ culture After 10 days of organ culture After 20 days of organ culture Total cell loss
I
 L 2400 2100 (Δ 300) 1750 (Δ 350) Δ 650
 R 2350 2000 (Δ 350) 1050 (Δ 950) Δ 1300
II
 L 2300 2100 (Δ 200) 1650 (Δ 550) Δ 650
 R 2450 2100 (Δ 350) 1400 (Δ 700) Δ 1050
III
 L 2200 2000 (Δ 200) 1350 (Δ 200) Δ 400
 R 2200 2000 (Δ 200) 1800 (Δ 650) Δ 850
IV
 L 2050 1500 (Δ 550) 1650 (Δ +150) Δ 400
 R 2050 1700 (Δ 350) 1600 (Δ 100) Δ 450
V
 L 2200 2000 (Δ 200) 1950 (Δ 50) Δ 250
 R 2050 2000 (Δ 50) 1250 (Δ 750) Δ 800
IV
 L 2150 1900 (Δ 250) 1800 (Δ 100) Δ 350
 R 2150 1900 (Δ 250) 1150 (Δ 750) Δ 1000

This Article

Register for free content


Free sample
This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.