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Br J Ophthalmol 81:145-149 doi:10.1136/bjo.81.2.145
  • Original Article
    • Laboratory science

Increased release of tumour necrosis factor-α in human tear fluid after excimer laser induced corneal wound

Table 1

Pre- and postoperative flows in the collection capillary, TNF-α concentrations, and TNF-α releases

No Sex/age Abl depth Tear fluid flow (μl/min) TNF concentration (ng/l) TNF release (pg/min)
Day 0 Day 2 Day 7 Day 0 Day 2 Day 7 Day 0 Day 2 Day 7
1 M/23 63 93.2 138.9 ND 285 350 ND 26.6 48.6 ND
2 F/37 70 23.6 51.7 26.1 350 350 <5 8.3 18.1 0.1
3 M/21 43 62.5 78.1 15.5 600 450 735 37.5 35.2 11.4
4 M/27 70 21.4 219.3 24.2 680 <5 <5 14.6 1.1 0.1
5 F/49 63 1.5 3.0 1.8 130 630 315 0.2 1.9 0.6
6 F/32 51 19.0 67.0 13.2 400 265 430 7.6 17.8 5.7
7 F/39 63 9.9 50.0 11.2 195 600 235 1.9 30.0 2.6
8 F/36 63 61.5 67.1 ND 460 330 ND 28.3 22.2 ND
9 F/37 81 4.6 100.0 9.3 365 365 220 1.7 36.5 2.1
10 F/37 85 8.6 25.6 15.6 260 540 195 2.2 13.9 3.1
11 F/21 125 14.3 43.0 5.8 375 385 260 5.4 16.6 1.5
12 M/21 50 17.9 111.1 ND 345 <5 ND 6.2 0.6 ND
13 M/21 63 9.3 166.7 ND 180 450 ND 1.7 75.0 ND
14 M/46 16 9.5 108.7 7.5 450 750 685 4.3 81.5 5.1
15 M/36 88 29.4 111.1 ND 680 620 ND 20.0 68.9 ND
16 F/21 73 8.1 37.7 41.7 110 385 610 0.9 14.5 25.4
17 F/31 88 7.1 24.5 ND 350 715 ND 2.5 17.5 ND
18 M/21 33 2.7 49.0 3.2 220 315 145 0.6 15.4 0.5
N 18 18 18 18 12 18 18 12 18 18 12
Mean 31 66 22.5 80.7 14.6 358 417 320 9.5 28.6 4.8
Median 32 63 12.1 67.1 12.2 350 385 248 4.9 18.0 2.4
SD 9 24 24.9 55.1 11.4 170 207 246 11.2 24.8 7.2
Range 21–49 16–125 1.5–93.2 3.0–219 1.8–41.7 110–680 <5–750 <5–735 0.2–37.5 0.6–81.5 0.1–25.4
p Value† 0.0002 NS NS NS 0.003 NS

  • ↵N is the number of patients. †The p values refer to comparisons of postoperative and preoperative samples of the same patients (Wilcoxon signed rank two group paired test).

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