Recurrent uveitis in a patient with adult onset cyclic neutropenia associated with increased large granular lymphocytes
- Immunology and Uveitis Service, Department of Ophthalmology. Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- Division of Rheumatology, Fallon Clinic, Worcester, MA, USA
- Division of Ophthalmology, Fallon Clinic, Worcester, MA, USA
- Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- Accepted 11 December 1996
- Immunology and Uveitis Service, Department of Ophthalmology. Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- Division of Rheumatology, Fallon Clinic, Worcester, MA, USA
- Division of Ophthalmology, Fallon Clinic, Worcester, MA, USA
- Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- Accepted 11 December 1996
- Immunology and Uveitis Service, Department of Ophthalmology. Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- Division of Rheumatology, Fallon Clinic, Worcester, MA, USA
- Division of Ophthalmology, Fallon Clinic, Worcester, MA, USA
- Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- Accepted 11 December 1996
- Immunology and Uveitis Service, Department of Ophthalmology. Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- Division of Rheumatology, Fallon Clinic, Worcester, MA, USA
- Division of Ophthalmology, Fallon Clinic, Worcester, MA, USA
- Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School. Boston, MA, USA
- C Stephen Foster, MD, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA.
- Accepted 11 December 1996
Editor,—A 35-year-old white man was referred with a 1 month history of recurrent bilateral uveitis.
The patient had a history of cyclic neutropenia beginning at age 19. Severe neutropenia (total neutrophil count as low as 68 cells × 106/l), lasting about 3 days, was documented to occur at the time of clinical symptoms. Prednisone produced a marked diminution in episodes of symptomatic neutropenia.
At age 35, the patient developed iritis in his left eye during a ‘crisis’. This was treated with 0.1% dexamethasone phosphate solution. The anterior chamber inflammatory reaction subsided, but 1+ cells persisted in the vitreous despite an injection …
