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Br J Ophthalmol 81:584-589 doi:10.1136/bjo.81.7.584
  • Original Article
    • Laboratory science

Effect of mitomycin C on the optic nerve in rabbits

Table 3

Results of visual evoked potential (VEP) testing in 15 rabbits, 10 of which received mitomycin C to the optic nerve sheath on one side without sheath fenestration. Steady state VEPs were performed at 40, 50, and 60 Hz for each eye (3 sets)

Group, treatment (see Table1) Eyes (n) Responses present p Value
3/3 2/3 1/3 0/3
Baseline before surgery 5 5 0 0 0  —
Unoperated fellow eyes 15 15 0 0 0 1.0
1 BSS 5 5 0 0 0 1.0
2 MMC 0.2 5 0 3 2 0 0.0001
3 MMC 0.5 5 0 0 4 1 0.0001
  • BSS = balanced salt solution; MMC = mitomycin C.

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