Table 3
Responses of ocular arteries to constrictor agonists
| Agonist | Artery | Species | Receptor | Mechanisms |
|---|---|---|---|---|
| Noradrenaline | Ophthalmic: | porcine, canine, feline | α1 | |
| Ciliary: | human | |||
| bovine, canine | α1 | |||
| Adrenaline | Ophthalmic: | canine, feline | ||
| Ciliary: | human, canine | |||
| Retinal: | porcine | |||
| Phenylephrine | Ophthalmic: | canine, feline | α1 | |
| Ciliary: | human, canine | α1 | ||
| Retinal: | bovine | α1 | ||
| α2Agonists | Ophthalmic: | canine, feline | No contraction | |
| Ciliary: | human, canine | No contraction | ||
| 5-HT | Ophthalmic: | human, feline | ||
| porcine | 5-HT2 | |||
| rabbit | 5-HT1/2 | |||
| Ciliary: | human | |||
| porcine, bovine | 5-HT2 | |||
| Retinal: | bovine | |||
| Histamine | Ophthalmic: | feline | ||
| Ciliary: | human | |||
| bovine | H1 | |||
| Angiotensin II | Ciliary: | human, bovine | ||
| porcine | AT1 | |||
| Retinal: | bovine | No contraction | ||
| feline | AT1 | |||
| Endothelin-1 | Ophthalmic: | human | PLC activation? | |
| porcine | ||||
| Ciliary: | porcine | Influx extracellular Ca2+ | ||
| Retinal: | bovine | Influx extracellular Ca2+ | ||
| PGF2α | Ophthalmic: | porcine, canine | ||
| Ciliary: | porcine, bovine, canine | |||
| Retinal: | bovine | |||
| PGD2 | Ophthalmic: | canine | ||
| PGE2 | Retinal: | bovine | ||
| TxA2/U46619 | Ophthalmic: | canine | ||
| Ciliary: | porcine | |||
| Retinal: | bovine |
-
α Adrenoceptor (α1/α2), 5-hydroxytryptamine (5-HT), 5-HT receptors (5-HT1/2), histamine receptor (H1), angiotensin II receptor (AT1), phospholipase C (PLC), prostaglandins (PG), thromboxane A2 (TxA2).
