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Br J Ophthalmol 82:39-42 doi:10.1136/bjo.82.1.39
  • Original Article
    • Clinical science

Short term comparative study of topical 2% carteolol with and without benzalkonium chloride in healthy volunteers

Table 3

Distant visual acuity, pupil diameter, aesthesiometry, Schirmer’s test, break up time, fluorescein test, and IOP after 3 days of treatment (SD)

Carteolol without benzalkonium Carteolol with benzalkonium
Distant visual acuity (/2O) Baseline 24.2  (1.6) 23.8  (2.2)
3 days 24.8 (2.0) 24.2 (2.2)
Pupil diameter (mm) Baseline 3.1 (0.8) 3.38 (0.75)
3 days 3.4 (0.5) 3.38 (0.44)
Aesthesiometry (mg/surface) Baseline 13.6 (2.3) 12.5 (1.9)
3 days 11.4 (0.6) 11.4 (0.9)
Schirmer’s test (mm at 5 minutes) Baseline 25.7 (11.7) 20.60 (12.68)
3 days 13.3 (10.4) 17.03 (13.91)
Break up time (seconds) Baseline 9.1 (0.2) 10.4 (5.9)
3 days 8.4 (5.7) 7.7 (5.5)
Fluorescein test (graded 0 to 4) Baseline 0 0
3 days 0.1 (0.3) 0.1 (0.4)
IOP (mm Hg) Baseline 13.8 (1.7) 13.7 (1.9)
3 days 12.4 (1.8) 12.4 (1.9)
  • Significantly decreased from baseline (p=0.04).

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