rss
Br J Ophthalmol 1998;82:82-87 doi:10.1136/bjo.82.1.82
  • Original Article
    • Laboratory science

Systemic and local immunological features of atopic dermatitis patients with ocular complications

  1. Eiichi Uchioa,
  2. Kanata Miyakawab,
  3. Zenro Ikezawab,
  4. Shigeaki Ohnoa
  1. aDepartment of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Japan, bDepartment of Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
  1. Eiichi Uchio, MD, Department of Ophthalmology, Yokohama City University School of Medicine, 3–9 Fuku-ura, Kanazawa, Yokohama 236, Japan.
  • Accepted 8 September 1997

Abstract

AIMS Clinical factors and data from recent cases of atopic dermatitis (AD) (with or without ocular complications) and non-AD cases were examined to evaluate the mechanism of atopic ocular complications.

METHODS IgE-RAST for eight allergens including rice, egg, and mite and serum total IgE were measured in 216 patients with AD (70 ocular type, 146 non-ocular type) and 69 non-AD individuals. Tear histamine and leukotriene B4(LTB4) levels were also measured.

RESULTS The serum levels of IgE were significantly increased in AD patients with ocular complications compared with those without ocular complications. The positive rates of IgE-RAST for rice and wheat were significantly higher in ocular type AD than in non-ocular type AD. In ocular type AD, serum IgE was significantly increased in patients with cataract compared with that in those without cataract. Tear histamine and LTB4 levels in AD patients with ocular complications showed significant elevations compared with those in patients with pure AD and controls.

CONCLUSIONS These results suggest that ocular type AD belongs to the most severe end of the spectrum of AD, and that some food antigens may contribute to the pathogenesis of severe AD resulting in ocular complications.

Footnotes

    This Article

    1. Abstract
    2. Full text
    3. PDF

    Responses

    1. Submit a response
    2. No responses published

    Social bookmarking

    Register for free content


    Free sample
     This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
    View free sample issue >>

    Free archive
    The full back archive is now available for BJO. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006, back to volume 1 issue 1.
    Register to access the free archive >>

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.