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Br J Ophthalmol 1998;82:106 doi:10.1136/bjo.82.2.106
  • Editorial

Growth factors in proliferative vitreoretinopathy

  1. DAVID G CHARTERIS
  1. Vitreoretinal Unit
  2. Moorfields Eye Hospital
  3. City Road
  4. London EC1V 2PD

      Surgical repair of retinal detachment complicated by proliferative vitreoretinopathy (PVR) remains complex and time consuming. Visual results of such surgery are frequently disappointing. Dissecting the network of growth factors/cytokines involved in PVR is a comparable challenge which may eventually result in improved anatomical and visual outcomes.

      Several lines of evidence point to a role for soluble mediators (“growth factors”) in the process of periretinal membrane formation seen in PVR. Firstly, studies of cellular healing responses in other tissues have demonstrated a role for a number of growth factors (sometimes termed “fibrogenic cytokines”) in mediating cellular chemotaxis and proliferation, neovascularisation, extracellular matrix production, wound remodelling, and contraction, processes essential to the normal wound healing response.1 2 Secondly, several in vitro investigations …

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