Table 3
Mean values of spirometry, blood, and IOP at 1 month and 1 year
| Treatment group | Enrolment (SD) | 1 Month (SD) | 1 Year (SD) | Change from enrolment (95% CI) | Significance of difference between groups at 1 year | ||
|---|---|---|---|---|---|---|---|
| Peak flow (l/min) | Timolol | 336 (97) | 305 (83) | 321 (93) | −15.0 (−29.0, −0.9) | p=0.34 | |
| Betaxolol | 295 (121) | 282 (114) | 287 (132) | −6.3 (−16.3, 3.7) | |||
| FEV1 (litres) | Timolol | 2.04 (0.50) | 1.92 (0.51) | 1.97 (0.51) | −0.07 (−0.12, −0.01) | p=0.29 | |
| Betaxolol | 1.68 (0.66) | 1.65 (0.63) | 1.65 (0.70) | −0.02 (−0.09, 0.05) | |||
| FVC (litres) | Timolol | 2.65 (0.73) | 2.53 (0.73) | 2.49 (0.62) | −0.17 (−0.30, −0.04) | p=0.42 | |
| Betaxolol | 2.34 (0.87) | 2.24 (0.83) | 2.23 (0.99) | −0.09 (−0.21, 0.02) | |||
| FEV1/FVC (% age) | Timolol | 75 (8) | 75 (8) | 79 (6) | 4.2 (1.3, 7.0) | p=0.99 | |
| Betaxolol | 70 (12) | 72 (11) | 74 (13) | 4.1 (0.0, 8.2) | |||
| Systolic BP (mm Hg) | Timolol | 153 (24) | 138 (23) | 142 (22) | −10.5 (−23.0, 2.0) | p=0.82 | |
| Betaxolol | 141 (22) | 135 (23) | 134 (19) | −8.7 (−18.1, 0.7) | |||
| Diastolic BP (mm Hg) | Timolol | 93 (10) | 84 (13) | 88 (13) | −5.0 (−10.8, 0.8) | p=0.85 | |
| Betaxolol | 88 (14) | 82 (11) | 83 (12) | −5.8 (−11.8, 0.3) | |||
| Pulse (beats/min) | Timolol | 80 (11) | 70 (10) | 74 (11) | −5.6 (−9.2, −2.0) | p=0.07 | |
| Betaxolol | 82 (10) | 78 (15) | 83 (12) | +0.2 (−4.9, 5.3) | |||
| IOP (mm Hg) | Timolol | 25 (4) | 19 (3) | 19 (3) | −5.7 (−7.8, −3.6) | p=0.96 | |
| Betaxolol | 24 (4) | 20 (4) | 19 (3) | −5.6 (−7.8, −3.5) | |||
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FEV1 = forced expiratory volume in one second; FVC = forced vital capacity.
