Multifocal electroretinography in patients with Stargardt’s macular dystrophy
- University Eye Hospital, Department for Pathophysiology of Vision and Neuro-Ophthalmology, Tuebingen, Germany
- Dr Ulf Kretschmann, University Eye Hospital, Department for Pathophysiology of Vision and Neuro-Ophthalmology, Schleichstrasse 12–16, 72076 Tuebingen, Germany.
- Accepted 29 September 1997
Abstract
AIMS To describe the topography of multifocal electroretinograms (ERGs) and to explore its diagnostic value in patients with Stargardt’s macular dystrophy (SMD).
METHODS 51 patients with SMD were examined by means of the m-sequence technique to characterise the topography of electroretinographic responses in the central visual field. The results were compared with data from 30 normal volunteers.
RESULTS In 49 of 51 patients with SMD, macular electroretinographic activity was markedly diminished or non-detectable. Towards more peripheral areas, ERG responses of the SMD patients approached those of normals. Implicit times were not markedly delayed at any eccentricity.
CONCLUSION In contrast with Ganzfeld electroretinography, multifocal electroretinography is useful to detect foveal dysfunction in SMD. Areas of dysfunction were found to be usually larger than expected from psychophysical measurements and morphological alteration. In early stages of the disease it was possible to detect foveal dysfunction, even in patients lacking morphological fundus changes and with good visual acuity.
