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Br J Ophthalmol 82:432-437 doi:10.1136/bjo.82.4.432
  • Original Article
    • Laboratory science

Adhesion molecules in iris biopsy specimens from patients with uveitis

Table 2

Expression of adhesion molecules in iris biopsy specimens from patients with uveitis or glaucoma

Adhesion molecules Uveitis (n=11) Glaucoma (n=8) p Value
Vascular endothelium
ICAM-1 10/11 (91%) 2/8 (25%) 0.0062
VCAM-1 4/11 (36%) 2/8 (25%) 0.49
HECA-452 3/7 (43%) 1/8 (12.5%) 0.23
Iris resident cells
LECAM 0/11 0/8 1.0
ICAM-1 11/11 (100%) 2/8 (25%) 0.0013
LFA-1α 6/11 (55%) 0/8 0.017
LFA-1β 1/11 (9%) 0/8 0.6
VCAM-1 7/11 (64%) 0/8 0.013
VLA-4 1/8 (12.5%) 0/8 0.58
Infiltrating mononuclear cells
LECAM 0/11 1/8 (12.5%) 0.42
ICAM-1 11/11 (100%) 2/8 (25%) 0.0013
LFA-1α 5/11 (45%) 1/8 (12.5%) 0.15
LFA-1β 1/11 (9%) 1/8 (12.5%) 0.68
VCAM-1 6/11 (55%) 2/8 (25%) 0.21
VLA-4 1/8 (12.5%) 2/8 (25%) 0.5

  • ↵Iris melanocytes, iris pigment epithelial cells, fibroblasts.

  • ↵Fisher’s exact test, without correction for multiple comparisons.

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