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Br J Ophthalmol 82:554-560 doi:10.1136/bjo.82.5.554
  • Original Article
    • Laboratory science

Effects of single, short term exposures of human retinal pigment epithelial cells to thiotepa or 5-fluorouracil: implications for the treatment of proliferative vitreoretinopathy

Table 4

Comparison between the effects of different concentrations of thiotepa and 5-FU on cell proliferation (colorimetric test) at day 14

Thiotepa Concentration of thiotepa (mg/ml)
Control 0.06 0.125 0.25 1.0 4.0
(A) 5 minute exposure to thiotepa:
 Concentration of thiotepa (mg/ml) 0.06
0.125
0.25
1.0
4.0
(B) 30 minute exposure to thiotepa:
 Concentration of thiotepa (mg/ml) 0.06
0.125
0.25
1.0
4.0
Concentration of 5-FU (mg/ml)
5-FU Control 0.25 2.5 5.0 10.0 25.0
(C) 5 minute exposure to 5-FU:
 Concentration of 5-FU (mg/ml) 0.25
2.5
5.0
10.0
25.0
(D) 30 minute exposure to 5-FU:
 Concentration of 5-FU (mg/ml) 0.25
2.5
5.0
10.0
25.0

  • ↵Denotes significant difference (p<0.05) between the two concentrations.

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