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Letter to the Editor
Spontaneous and sustained resolution of CMV retinitis in patients receiving highly active antiretroviral therapy
  1. SCOTT M WHITCUP
  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  2. Francis I Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, CA, USA
  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
  4. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  1. EMMETT T CUNNINGHAM JR
  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  2. Francis I Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, CA, USA
  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
  4. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  1. MICHAEL A POLIS
  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  2. Francis I Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, CA, USA
  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
  4. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  1. ERIC FORTIN
  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  2. Francis I Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, CA, USA
  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
  4. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  1. Scott M Whitcup, MD, National Eye Institute, 10 Center Drive, Bldg 10 Rm 10N 202, Bethesda, MD 20892-1858, USA.

https://doi.org/10.1136/bjo.82.7.841f

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    Editor,—Cytomegalovirus (CMV) retinitis predominantly occurs in severely immunocompromised patients with CD4+ counts below 50 cells ×106/l. Before the use of combinations of protease inhibitors and other antiretroviral agents, CMV retinitis invariably progressed in the absence of specific anti-CMV therapy. This highly active antiretroviral therapy (HAART) can decrease human immunodeficiency virus (HIV) load and increase CD4 T cell counts in patients with AIDS.1 2 In this study we describe two patients receiving HAART, who present with probable inactive CMV retinitis although they never received anti-CMV therapy. In one of these patients, CMV retinitis recurred shortly after his CD4+ cell counts fell below 50 cells ×106/l despite continued combination antiretroviral therapy.

    case reports

    Patient No 1

    A 28 year old man with AIDS and a history of one positive blood culture for CMV and a CD4+ cell count of 13 …

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