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Br J Ophthalmol 83:115-119 doi:10.1136/bjo.83.1.115
  • Original Article
    • Laboratory science

Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial dystrophy (CHED) and autosomal dominant CHED are genetically distinct

Table 1

Two point LOD scores for linkage between recessive congenital hereditary endothelial dystrophy and five microsatellite markers on chromosome 20

Marker Recombination fraction (θ)
0.00 0.01 0.05 0.10 0.20 0.30 0.40 θ min
D20S98 −999.99 −3.959 −1.394 −0.414 0.265 0.322 0.175 0.033
D20S114 −999.99 −5.458 −2.164 −0.892 0.041 0.250 0.183 0.054
D20S471 −999.99 −5.290 −2.082 −0.922 −0.110 0.092 0.084 0.052
D20S195 −999.99 −12.862 −6.277 −3.667 −1.459 −0.555 −0.172 0.165
D20S96 −999.99 −8.154 −3.009 −1.133 0.224 0.535 0.375 0.071

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