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Br J Ophthalmol 1999;83:1183-1185 doi:10.1136/bjo.83.10.1183
  • Scientific correspondence

Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid

  1. Osman Çekiça,
  2. Cosar Batmana,
  3. Ümit Yasarb,
  4. Yüksel Totana,
  5. Nursabah E Bascib,
  6. Atilla Bozkurtb,
  7. Orhan Zilelioglua,
  8. S Oguz Kayaalpb
  1. aSSK Ankara Eye Hospital, Department of Vitreoretinal Surgery, Ankara, Turkey, bHacettepe University, Faculty of Medicine Department of Pharmacology, Ankara, Turkey
  1. Osman Çekiç, MD, 54 Basak Sokak, No 7, 06660 Kucukesat Ankara, Turkey
  • Accepted 25 June 1999

Abstract

AIMS To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration.

METHODS 31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were analysed for drug level by using high performance liquid chromatography.

RESULTS SRF drug levels after oral and combined administration were significantly higher than that after topical administration (p=0.0002 and p=0.0002, respectively) while there was no significant difference between oral and combined administration (p=0.0844).

CONCLUSIONS Ocular bioavailability of ofloxacin in SRF after oral and combined administration is equivalent. The addition of oral ofloxacin to topical therapy increased drug SRF penetration sixfold.

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