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Br J Ophthalmol 83:1183-1185 doi:10.1136/bjo.83.10.1183
  • Scientific correspondence

Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid

Table 1

Subretinal fluid ofloxacin concentrations (μg/ml) in treatment groups

Patient No Topical
ofloxacin
Patient No Oral
ofloxacin
Patient No Topical+oral ofloxacin
1 0.16 1 0.94 1 1.87
2 0.34 2 1.13 2 4.78
3 0.73 3 1.29 3 2.29
4 0.61 4 3.65 4 1.11
5 0.29 5 2.16 5 1.56
6 0.32 6 0.98 6 3.41
7 0.29 7 1.02 7 1.18
8 0.41 8 2.12 8 3.01
9 0.33 9 0.99 9 4.02
10 1.11 10 2.88
11 2.19 11 1.05
Mean (SEM) 0.39 (0.06) Mean (SEM) 1.60 (0.26) Mean (SEM) 2.47 (0.38)
  • Two drops of 0.3% solution every 30 minutes for 3 hours and every 60 minutes for the next 3 hours before surgery.

  • A single dose 400 mg 8 hours before surgery.

  • A single dose 400 mg 8 hours before surgery and two drops of 0.3% solution every 30 minutes for 3 hours and every 60 minutes for the next 3 hours before surgery.

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