Verbraak, Frank D; Boom, René; Dillen, Pauline M E Wertheim-van; van den Horn, Gerardus J; Kijlstra, Aize; de Smet, Marc D

Table 2

Effect of HAART on CD4+ cell counts and CMV viral load in 22 HIV positive patients, without anti-CMV maintenance therapy, at high risk for developing CMV disease

Patient No		Before HAART				After HAART				Last exam
		Exam 0				Exam 1				Exam 2	Exam 3	Exam 4		Exam 5	Exam 6	Exam 7		After n months	PCR	CD4+
		CD4+	PCR			CD4+	PCR			PCR	PCR	CD4+	PCR	PCR	PCR	CD4+	PCR	After n months	PCR	CD4+
1	10	1469		70	—	—	—	110	—	—	—	230	—		18	—	130
2	150	914		150	—	—	—	140	—	—	—	180	—		18	—	150
3	20	1136		210	—	—	—	250	—	—	—	250	—		12	—	170
4	20	562		90	—	—	—	220	—	—	—	ND	—		9	—	460
5	40	1529		160	—	—	—	130	—	—	171	140	—		18	—	170
6	40	382		30	2071	1474	ND	ND	ND	ND	ND	100	—		12	—	100
7	40	2355		100	—	—	376	150	584	—	—	170	—		16^#	—	180
8	90	1259		170	384	—	—	200	—	—	—	190	—		22	—	200
9^*	30	1423		90	—	—	947	100	—	ND	ND	ND	ND		13	—	100
10^*	20	604		140	133	—	—	200	—	—	—	200	—		16	—	200
11	30	—		10	—	—	237	ND	ND	—	—	ND	ND		12	—	180
12	20	—		60	6488	1464	—	130	534	602	—	140	—		13	—	120
13	20	—		30	—	186	875	40	—	346	—	20	—		16	727	60
14	10	—		110	—	—	—	260	—	—	—	170	—		16^*	—	340
15	20	—		60	—	—	—	90	—	—	—	80	—		17	—	250
16	50	—		190	—	ND	ND	130	—	ND	ND	ND	ND		9	—	130
17	30	—		70	—	—	—	150	—	—	—	170	—		16	—	110
18	10	—		230	—	—	—	60	—	—	—	170	—		18	—	250
19	10	—		80	—	—	ND	100	—	—	—	130	—		13	—	190
20	30	—		140	—	—	ND	ND	ND	ND	ND	ND			8	—	140
21	30	—		50	—	—	—	80	—	—	—	ND	—		14	—	130
22^*	30	—		120	—	—	—	190	—	148	—	400	—		22	—	500

CD4+ = CD4+ cell count (cells ×10⁶/l); HAART = highly active antiretroviral therapy; PCR = quantitative polymerase chain reaction, in copies CMV ×10⁶/ml; − = negative result; ND = not done; exam 0 = first examination, at intake, before the start of HAART; exam 1–7 = examinations, monthly, after the start of HAART. After the 7th examination, follow up scheduled every other month, results not shown. ^*Patient 9, 10, and 22 previous diagnosis of extraocular CMV disease.;^†patient 7 one positive test 12 months after start HAART (280 copies/ml);
patient 14 one positive test 14 months after start HAART (98 copies/ml); last exam after n months = last examination of the patient at n months after the start of HAART.

Influence of highly active antiretroviral therapy on the development of CMV disease in HIV positive patients at high risk for CMV disease

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