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Br J Ophthalmol 1999;83:1194 doi:10.1136/bjo.83.10.1194k
  • Letter to the Editor

Late onset of Leber’s hereditary optic neuropathy in HIV infection

  1. CHRISTOPH LÜKE
  1. Klinik und Poliklinik für Augenheilkunde
  2. Klinik I für Innere Medizin, Universität Köln, Germany
  3. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  4. Molekulargenetisches Labor, Universitätsaugenklinik Tübingen, Germany
  5. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  • Accepted 17 June 1999
  1. OLIVER A CORNELY
  1. Klinik und Poliklinik für Augenheilkunde
  2. Klinik I für Innere Medizin, Universität Köln, Germany
  3. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  4. Molekulargenetisches Labor, Universitätsaugenklinik Tübingen, Germany
  5. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  • Accepted 17 June 1999
  1. JULIA FRICKE,
  2. ELFI LEHRER,
  3. KARL ULRICH BARTZ-SCHMIDT
  1. Klinik und Poliklinik für Augenheilkunde
  2. Klinik I für Innere Medizin, Universität Köln, Germany
  3. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  4. Molekulargenetisches Labor, Universitätsaugenklinik Tübingen, Germany
  5. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  • Accepted 17 June 1999
  1. BERND WISSINGER
  1. Klinik und Poliklinik für Augenheilkunde
  2. Klinik I für Innere Medizin, Universität Köln, Germany
  3. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  4. Molekulargenetisches Labor, Universitätsaugenklinik Tübingen, Germany
  5. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  • Accepted 17 June 1999
  1. RICHARD BRUNNER
  1. Klinik und Poliklinik für Augenheilkunde
  2. Klinik I für Innere Medizin, Universität Köln, Germany
  3. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  4. Molekulargenetisches Labor, Universitätsaugenklinik Tübingen, Germany
  5. Klinik und Poliklinik für Augenheilkunde, Universität Köln, Germany
  1. Christoph Lüke, Klinik und Poliklinik für Augenheilkunde, Universität Köln, Joseph-Stelzmann Strasse 9, D-50924 Köln, Germany
  • Accepted 17 June 1999

Editor,—We report a case of late onset of Leber’s hereditary optic neuropathy (LHON) in a 59 year old patient with HIV infection being treated long term since 1991 with zidovudine. The onset and course of the patient’s eye disease as well as the diagnostic process were analysed. Molecular genetic testing revealed the mitochondrial DNA (mtDNA) mutation in nucleotide position 11778 confirming the diagnosis of LHON. In our patient late disease expression may be interpreted as a result of the rare combination of the 11778 mutation with HIV infection and long term zidovudine treatment. This is the first report on a patient with LHON suffering from additional HIV infection.

CASE REPORT

A 59 year old white man was admitted to our outpatient department in July 1997 with acute onset of vision loss in his left eye within the previous 2 weeks. The …

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