Macular dystrophy of malattia leventinese. A 25 year follow up

Editor,—Macular degeneration is a clinical term used to describe a variety of diseases characterised by progressive loss of central vision associated with abnormalities of Bruch’s membrane and the retinal epithelium. This dominantly inherited disorder, characterised by a radial pattern of innumerable small elongated basal laminar drusen, was initially reported in a family from the Leventine Valley (Switzerland).1 2 The gene responsible for autosomal dominant malattia leventinese has been mapped to the short arm of chromosome 2p16–21.3 4 We report the case of a woman who developed unusual complications associated with this disease during a 25 year follow up.