Macular dystrophy of malattia leventinese. A 25 year follow up
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Hôpital de la Croix Rousse, Lyons, France
- Hôpital de l’Hôtel-Dieu, Service de Génétique
- Lyons, France
- Hôpital de la Croix Rousse Lyons, France
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Accepted 21 May 1999
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Hôpital de la Croix Rousse, Lyons, France
- Hôpital de l’Hôtel-Dieu, Service de Génétique
- Lyons, France
- Hôpital de la Croix Rousse Lyons, France
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Accepted 21 May 1999
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Hôpital de la Croix Rousse, Lyons, France
- Hôpital de l’Hôtel-Dieu, Service de Génétique
- Lyons, France
- Hôpital de la Croix Rousse Lyons, France
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Accepted 21 May 1999
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Hôpital de la Croix Rousse, Lyons, France
- Hôpital de l’Hôtel-Dieu, Service de Génétique
- Lyons, France
- Hôpital de la Croix Rousse Lyons, France
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Accepted 21 May 1999
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Hôpital de la Croix Rousse, Lyons, France
- Hôpital de l’Hôtel-Dieu, Service de Génétique
- Lyons, France
- Hôpital de la Croix Rousse Lyons, France
- Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Lyons, France
- Dr Jean-Christophe Zech, Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Service d’Ophtalmologie, Pavillon C, Place d’Arsonval 69437 Lyon cedex 03 France.
- Accepted 21 May 1999
Editor,—Macular degeneration is a clinical term used to describe a variety of diseases characterised by progressive loss of central vision associated with abnormalities of Bruch’s membrane and the retinal epithelium. This dominantly inherited disorder, characterised by a radial pattern of innumerable small elongated basal laminar drusen, was initially reported in a family from the Leventine Valley (Switzerland).1 2 The gene responsible for autosomal dominant malattia leventinese has been mapped to the short arm of chromosome 2p16–21.3 4 We report the case of a woman who developed unusual complications associated with this disease during a 25 year follow up.
CASE REPORT
In 1973, ophthalmological examination led to a diagnosis of bilateral hereditary macular dystrophy (malattia leventinese) in a woman born in 1943. Her visual acuity was …









