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Br J Ophthalmol 83:1370-1375 doi:10.1136/bjo.83.12.1370
  • Original Article
    • Laboratory science

Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, orl-ornithine

Table 6

Mean diameter of collagen fibrils (nm)

Anterior sclera
Mean (SD)
Posterior sclera
Mean (SD)
Control 194 (65) 121 (38)
7-Methylxanthine 163 (70) p<0.0001 171 (48) p<0.0001
Theobromine 156 (72) p<0.0001 194 (53) p<0.0001
Acetazolamide 171 (58) p<0.0001 94 (32) p<0.0001
l-ornithine 172 (49) p<0.0009 87 (30) p<0.0001
p Value in Kruskal–Wallis H test <0.0001 <0.0001
  • Indicates p values from exact Mann–Whitney test in comparison with controls.

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