Table 3
Summary of studies evaluating the outcome of guarded filtration procedures with mitomycin C in children
| Author | No of patients/eyes | Type of glaucoma | Procedure | Criteria of success | % of successful cases (months of follow up) |
|---|---|---|---|---|---|
| Mandal et al | 13/19 | Congenital and developmental | GFP with mm C | IOP <21 mm Hg at slit lamp or | 94% (19) |
| 3 min, 0.4 mg/ml | <16 mm Hg under anaesthesia | ||||
| Susannaet al | 68/98 | Congenital and developmental | GFP with mm C | IOP <22 mm Hg | 67% (17) |
| 5 min, 0.2 mg/ml | |||||
| Agarwalet al | 16/30 | Congenital and developmental | GFP with mm C* | IOP <21 mm Hg without meds | |
| 4 min, 0.2 mg/ml | 60% (18) | ||||
| 4 min, 0.4 mg/ml | 86% (18) | ||||
| Asrani and Wilensky | (?)/14 | ||||
| 7 | Aphakic | GFP with mm C | IOP <22 mm Hg | 85% (?) | |
| 5 | Aphakic | GFP | 60% (?) | ||
| Wallace et al | (?)/13 | Aphakic | GFP with mm C | IOP <26 mm Hg without meds | 61% (?) |
| 4 min, 0.2–0.4 mg/ml | or IOP <21 mm Hg with meds | ||||
| Walton | (?)/14 | Aphakic | GFP with mm C | (?) | 64% (?) |
| (?) | |||||
| Azuara-Blancoet al | 21/21 | ||||
| 13 | Congenital, developmental | GFP with mm C, | IOP <21 mm Hg without meds | 76% (18) | |
| 8 | Aphakic | 1–5 min, 0.4 mg/ml | 0% (18) |
-
GFP = guarded filtration procedure; mm C = mitomycin C; IOP = intraocular pressure; meds = antiglaucoma medications; (?) = not mentioned in the study; *filtration surgery was associated with trabeculotomy.
