Studies of association between diabetes mellitus, intraocular pressure, and glaucoma
| Author(s) | Published | Location | Method | Numbers | Ascertainment | Association POAG? | OR | Association IOP? | OR | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diabetes | POAG | ||||||||||||||||||
| Waiteet al | 1935 | Massachusetts | clinic | 2002 | clinic | 1, 2, 3 | no | NA | NA | NA | |||||||||
| Palomar | 1956 | Spain | clinic | 416 | clinic | 1 | no | NA | yes lower in DM | NA | |||||||||
| Armstrong et al | 1960 | Texas | clinic | 998 | clinic | 1, 2, 3 | yes | 2.9 | \ | \ | |||||||||
| Sugar | 1964 | — | — | — | — | — | yes | NA | — | — | |||||||||
| Newell | 1965 | — | — | — | — | — | yes | NA | — | — | |||||||||
| Becker | 1966 | Washington | clinic | 304 | clinic | 1, 2 | — | — | yes higher in DM | NA | |||||||||
| Safiret al | 1966 | New York | clinic | 107 | clinic | 1 | — | — | yes higher in DM | NA | |||||||||
| Armaly and Baloglou | 1967 | Lebanon | clinic | 390 | clinic | 1 | — | — | yes lower in DM | NA | |||||||||
| Bankes | 1968 | Bedford | Community | 3072 | Urinalysis, GTT | 1, 2, 3 | — | — | no difference | — | |||||||||
| Bouzaset al | 1971 | Boston | clinic | 101 | clinic | 1 | — | — | no difference | — | |||||||||
| Morgan and Drance | 1975 | Canada | Mixed | NS | Interview | 1, 2, 3 | no | NA | — | — | |||||||||
| Leske and Podgor | 1983 | Framingham | Community | 2315 | GTT | 1, 3 | no | NA | yes higher in DM | 2.3 | |||||||||
| Kleinet al | 1984 | Winsconsin | Community | 2747 | clinic | 1 | yes | 1.84 | yes higher in DM | NA | |||||||||
| David et al | 1987 | Israel | Community | 2547 | Interview | 1, 2 | — | — | yes higher in DM | 1.58 | |||||||||
| Wilsonet al | 1987 | Boston | clinic | 441 | Interview | 1, 2 | yes | 1.6 | — | — | |||||||||
| Klein et al | 1994 | Beaver Dam | Community | 4926 | HbA1c, RBG | 1, 2, 3 | yes | 1.68 | yes higher in DM | NA | |||||||||
| Tielschet al | 1994 | Baltimore | Community | 5308 | Interview | 1, 2, 3 | no | 1.03 | yes higher in DM | 1.53 | |||||||||
| Dielmanset al | 1996 | Rotterdam | Community | 4012 | GTT | 1, 2, 3 | yes | 3.11 | yes higher in DM | 0.31 mm Hg | |||||||||
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↵Criteria required for diagnosis of POAG: 1 (IOP), 2 (disc changes), 3 (field changes).
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↵Field defects not correlated with diabetes.
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↵Authors’ calculation from published figures.
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↵Children and young type 1 diabetic patients included.
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↵No non-diabetic controls.
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↵624 patients excluded because IOP measurement unreliable.
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↵ Reported glaucoma—not examined by authors.
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↵8.5% Diabetic patients IOP >21 mm Hg cf 4.3% IOP >21 mm Hg controls.
