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Br J Ophthalmol 83:486-494 doi:10.1136/bjo.83.4.486
  • Original Article
    • Laboratory science

Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathy

Table 3

Mean intensity (SD) of FLT-4 staining in the retina/choroid

Choroid RPE Photo receptors Outer nuclear layer Inner nuclear layer Ganglion
cell layer
Retinal vessels Membrane vessels Membrane extravascular matrix
Non-diabetic (n=10) 0.30 (0.46) 0 (0) 0 (0) 0.10 (0.30) 0.90 (0.94) 0.50 (0.67) 0.70 (1.0)
No overt retinopathy (n=12) 0.42 (0.49) 0.08 (0.28) 0.33 (0.75) 0 (0) 1.50 (0.76) 1.83 (0.80) 1.0 (0.71)
Intraretinal changes (n=5) 0.20 (0.40) 0.20 (0.40) 0.60 (0.80) 0 (0) 1.80 (1.17) 2.0 (1.10) 1.20 (1.47)
PDR (n=6) 1.0 (0.82) 0.17 (0.37) 0 (0) 0 (0) 0.33 (0.47) 1.0 (0.82) 1.50 (1.12) 1.50 (1.26) 0.33 (0.47)
Laser, no residual PDR (n=14) 0.57 (0.62) 0.29 (0.45) 0.21 (0.56) 0.21 (0.41) 0.86 (0.64) 0.79 (0.56) 0.93 (0.80)
PDR excised membranes (n=11) 1.73 (0.96) 0.18 (0.39)
  • 0=background staining; 1=weak staining; 2=moderate staining; 3=intense staining.

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