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Diagnosis of corticosteroid resistant ocular sarcoidosis by chorioretinal biopsy
  1. SCOTT M WHITCUP,
  2. CHI-CHAO CHAN
  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  2. Brockwood Eye Institute, Birmingham, AL, USA
  1. GREER L GEIGER
  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA
  2. Brockwood Eye Institute, Birmingham, AL, USA
  1. Scott M Whitcup, MD, National Institutes of Health/National Eye Institute, 10/10S221 10 Center Dr MSC 1863, Bethesda, MD 20892–1863, USA.

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Editor,—Sarcoidosis, a multisystem granulomatous disease, involves the eye in approximately 25% to 50% of patients1 2 and produces numerous ocular findings.3 Definitive diagnosis requires a non-caseating granuloma in the absence of mycobacterial infection on biopsy. Although most patients have abnormal chest x rays, ocular sarcoidosis can precede pulmonary involvement, making diagnosis difficult. The following patient with ocular sarcoidosis—unresponsive to corticosteroids and cyclosporine—was diagnosed only after chorioretinal biopsy; she responded to azathioprine therapy.

CASE REPORT

A 32 year old white woman had a 12 year history of granulomatous uveitis in both eyes, resistant to treatment with topical, periocular, and systemic corticosteroids, as well as systemic cyclosporine. The patient presented …

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