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A new substrain of the non-obese diabetic mouse which develops cataracts (NOD/Ba/Lop19)
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Editor,—The non-obese diabetic (NOD) mouse is a spontaneous model of type 1 (insulin dependent) diabetes mellitus, frequently used in diabetes research.1 The colony at the medical college of St Bartholomew’s Hospital (NOD/Ba) was established in 1987 and some 55% of females and 15% of male mice spontaneously develop diabetes by 30 weeks of age.2 Cataracts are not a characteristic normally found in NOD mice but were observed during routine inspection …