Editor,—Apraclonidine hydrochloride 1% (Iopidine) is a selective α₂-adrenergic agonist used to treat glaucoma or to protect against pressure spikes before laser treatments. Up to 48% of patients taking Iopidine for over 3 weeks develop follicular conjunctivitis.1 2 Periocular contact dermatitis was also associated with Iopidine allergy in 62% of the cases.2 We report a case of an Iopidine allergic reaction presenting with eyelid ectropion which further progressed to cicatricial entropion.