Article Text
Letter to the Editor
Can leucocoria be the first manifestation of protein C deficiency?
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Editor,—Protein C is a plasma inhibitor protein that, once activated, inhibits clot formation and enhances fibrinolysis. Protein C deficiency has two forms. The homogeneous form presents in the neonatal period with ecchymotic-necrotic skin lesions and widespread thrombosis in major blood vessels with very low or undetectable protein C activity. Heterozygote individuals have protein C levels of approximately 50% and usually remain asymptomatic until adolescence.1
We present a neonate with homozygous protein C deficiency whose initial finding was leucocoria.
CASE REPORT
A 2 day old female infant was referred to Gazi University Hospital Division of Newborn Medicine with bullous …