Table 1
Summary of application techniques of intraoperative antimetabolites
| Study | MMC/ 5-FU | Sponge Size Stated | Sponge make specified | Application duration | Application technique notes |
| Cohen31 | MMC | 2×5 mm | Cellulose | 2.5 minutes | Excess liquid mopped up with second sponge |
| Lamping2 | MMC | No | Weck | 2.5 minutes | |
| Smith32 | 5-FU | No | Cellulose | 5 minutes | |
| Mora33 | 5-FU | No | Weck or instrument wipe | 5 minutes | |
| Madhavan25 | MMC | No | No | 1-3 minutes | Concentration varied 0.2–0.4 mg/ml |
| Dreyer34 | MMC | No | Gelfoam, Gelatin | 5 minutes | |
| Greenfield35 | MMC | Surgical spear | Weck | 5 minutes | |
| Campagna28 | MMC | No | Weck | 3.5 or 5 minutes | Time depends on surgeon |
| Mietz18 | MMC | 4×5×1 mm | Geuder | 3-5 minutes | MMC added to dry sponge after sponge placed on eye |
| Joos36 | MMC | No | Alcon, Cellulose | 5 minutes | |
| Munden24 | MMC | No | Cellulose | 3.5 or 5 minutes | |
| Lederer26 | MMC | 4×2×1 mm | Cellulose | 2–5 minutes | Sponge irrigated with saline during application |
| Kupin37 | MMC | 2×3×7 mm | Weck | 3 minutes | size when wet |
| Lachkar38 | 5-FU | 4.5×4.5 mm | No | 5 minutes | |
| Shin15 | MMC | 2×3×7 mm | Cellulose | 1, 3, 5 minutes | Size when wet. Comparison of application times |
| Costa39 | MMC | 3×2 mm | Weck-Cel | 3 minutes | |
| Megevand11 | MMC | 4.5×4.5 mm | Surgical sponge | 2 or 5 mins | |
| Chen17 | MMC | No | Gelfoam | 5 minutes | More than one piece of sponge used. Pieces replaced every minute |
| Kitazawa16 | MMC | No | Spongel | 5 minutes | 0.2 or 0.02 mg/ml used |
| Kitazawa40 | MMC | No | Spongel | 5 minutes | |
| Zacharia7 | MMC | No | Weck-cell or Mentor O & O | 3.5–7 minutes | Either 15 or 250 ml of irrigation applied |
| Robin13 | MMC | No | Cellulose | 4 minutes | Sponge replaced after 2 minutes |
