Table 4
Changes in corneal epithelial area, barrier function, and tear function tests in eyes with diabetes mellitus and dry eye
| Weeks | Timolol | Unoprostone | |||||||
|---|---|---|---|---|---|---|---|---|---|
| DM/DE (+) | DM/DE (−) | DM/DE (+) | DM/DE (−) | ||||||
| BUT (s) | 0 | 6.80 (2.4) | 7.33 (4.4) | 5.71 (2.6) | 7.77 (3.9) | ||||
| 12 | 6.25 (1.0) | 6.09 (3.8) | 5.50 (3.3) | 7.56 (5.2) | |||||
| 24 | 5.00 (1.0) | 4.50 (3.4) | 8.20 (5.2) | 6.78 (2.7) | |||||
| Schirmer's test (mm/5 min) | 0 | 13.8 (5.3) | 12.1 (9.4) | 13.9 (10.2) | 17.7 (11.6) | ||||
| 12 | 10.8 (5.6) | 9.00 (3.9) | 13.2 (12.4) | 19.3 (10.9) | |||||
| 24 | 10.0 (2.0) | 7.00 (2.9) | 15.2 (11.9) | 16.6 (9.0) | |||||
| Tear clearance test (log2) | 0 | 2.20 (0.8) | 3.20 (1.0) | 3.71 (1.9) | 3.25 (1.5) | ||||
| 12 | 1.00 (0.8) | 3.20 (1.1) | 4.00 (1.6) | 3.33 (1.3) | |||||
| 24 | 1.67 (2.08) | 2.38 (1.1) | 4.60 (1.7) | 3.64 (1.6) | |||||
| Tear function index | 0 | 31.6 (18.5) | 43.9 (44.5) | 56.1 (70.6) | 59.1 (49.5) | ||||
| 12 | 10.3 (8.2) | 29.6 (18.0) | 65.4 (82.4) | 56.7 (48.6) | |||||
| 24 | 16.0 (21.2) | 17.8 (14.0) | 81.0 (78.6) | 53.9 (38.2) | |||||
