Postmortem histological survey of the ocular lesions in a British population of AIDS patients
- aInstitute of Ophthalmology, Department of Pathology, Bath Street, London EC1V 9EL, UK, bDepartment of Experimental Medicine and Pathology, University “La Sapienza”, Viale Regina Elena, 324-00161 Rome, Italy, cDepartment of Histopathology, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, UK
- Dr Irene Pecorella, Dipartimento di Medicina Sperimentale e Patologia, Università degli Studi “La Sapienza”, V le Regina Elena, 324 00161 Rome, Italyirenepecorella{at}vregilio.it
- Accepted 4 May 2000
Abstract
AIMS To study ocular pathology and systemic correlations in a series of 73 postmortem eyes from British patients who died from AIDS before the introduction of a HAART regimen.
METHODS The eyes were studied with conventional histology, special histochemical stainings, and immunohistochemistry.
RESULTS 72.6% of the cases showed chronic uveal inflammation, caused by opportunistic agents in 37.7% of them (cytomegalovirus (CMV) in 30.1%,C neoformans in 5.6%, and Gram positive bacteria in 1.8%). Cytoid bodies were noted in 10/73 eyes, three linked to CMV retinitis. Six retinal haemorrhages, four of which were secondary to CMV, were found. 14 specimens (19.1%) showed foci of calcification, and a further 11 (15%) calcium oxalate deposits. In no cases were the calcific deposits suspected clinically. Six eyes (8.2%) did not show any abnormality.
CONCLUSIONS CMV retinitis is the most common (28.7%, 21/73) ocular infection in this series and may occur either during or in the absence of systemic dissemination. Conversely, ocular cryptococcosis appears to be an epiphenomenon of systemic and CNS disease. No other opportunistic ocular infections were present in this series. Interesting findings were the presence of intraocular precipitates of calcium oxalate and calcium phosphate or carbonate in a significant number of cases (15% and 19%, respectively), and the high prevalence of idiopathic uveal inflammation (43.8%).
