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Br J Ophthalmol 2000;84:1282-1284 doi:10.1136/bjo.84.11.1282
  • Original Article
    • Clinical science

Ocular pulse amplitude in diabetes mellitus

  1. Karl-Georg Schmidta,
  2. Andrea von Rückmannb,
  3. Bettina Kemkes-Matthesc,
  4. Hans-Peter Hammesd
  1. aNuffield Laboratory of Ophthalmology, Walton Street, University of Oxford, UK, bMoorfields Eye Hospital, City Road, London EC1V2PD, UK, cDepartment of Internal Medicine, Klinikstrasse 36, Justus Liebig University, D-35385 Giessen, Germany, dDepartment of Internal Medicine, Rodthohl 6, Justus Liebig University, D-35385 Giessen, Germany
  1. Dr med K-G Schmidt, Nuffield Laboratory of Ophthalmology, Walton Street, Oxford OX2 6AW, UKkarl-georg.schmidt{at}eye.ox.ac.uk
  • Accepted 15 May 2000

Abstract

BACKGROUND The influence of diabetes mellitus on ocular pulse amplitude (OPA), an indirect measure of choroidal perfusion, is unclear.

METHODS OPA, using the Langham ocular blood flow (OBF) system, applanation intraocular pressure (IOP), systemic blood pressure (BP), heart rate, and haemoglobin (Hb) A1c were measured in patients with insulin dependent diabetes mellitus (IDDM) with no (DR-0, n = 22) non-proliferative (DR-1, n = 24), and proliferative (DR-2, n = 18) diabetic retinopathy.

RESULTS Neither local (OPA, IOP) nor systemic perfusion parameters (BPs, HR) nor HbA1c were significantly altered in DR-0, DR-1, or DR-2 IDDM patients.

CONCLUSION Choroidal circulation remains unaffected as diabetic retinopathy advances.

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