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Br J Ophthalmol 2000;84:1423-1425 doi:10.1136/bjo.84.12.1423
  • Scientific correspondence

Increase of macrophage migration inhibitory factor in sera of patients with iridocyclitis

  1. Nobuyoshi Kitaichia,
  2. Satoshi Kotakea,
  3. Yuka Mizuec,
  4. Hidehiko Matsudaa,
  5. Kazunori Onoéd,
  6. Jun Nishihirab
  1. aDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine, bCentral Research Institute, Hokkaido University School of Medicine, cSapporo Immunodiagnostic Laboratory, Co, Ltd, dDivision of Immunobiology, Institute for Genetic Medicine, Hokkaido University
  1. Dr Kazunori Onoé, Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japankazunori{at}imm.hokudai.ac.jp
  • Accepted 16 June 2000

Abstract

AIMS To determine whether macrophage migration inhibitory factor (MIF) levels were increased in sera of the patients with iridocyclitis.

METHODS Sera were obtained from 41 patients with acute iridocyclitis, 13 patients with chronic iridocyclitis, and 44 healthy control subjects. MIF levels were determined by a human MIF ELISA.

RESULTS The average levels of MIF in the sera of patients with both acute and chronic iridocyclitis were significantly higher than that of healthy subjects.

CONCLUSION Uveitis induces the elevation of serum MIF, which may affect various inflammatory symptoms in uveitis.

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