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Letter to the Editor
Complete regression of retinal neovascularisation after therapy with interferon alfa in Behçet's disease
  1. NICOLE STUEBIGER
  1. University Eye Hospital Tuebingen, Department I (department of general ophthalmology), Tuebingen, Germany
  2. University Medical Hospital Tuebingen, Department II (department of hematology, oncology, rheumatology and immunology), Tuebingen
  3. University Eye Hospital Tuebingen, Department I (department of general ophthalmology)
  1. INA KOETTER
  1. University Eye Hospital Tuebingen, Department I (department of general ophthalmology), Tuebingen, Germany
  2. University Medical Hospital Tuebingen, Department II (department of hematology, oncology, rheumatology and immunology), Tuebingen
  3. University Eye Hospital Tuebingen, Department I (department of general ophthalmology)
  1. MANFRED ZIERHUT
  1. University Eye Hospital Tuebingen, Department I (department of general ophthalmology), Tuebingen, Germany
  2. University Medical Hospital Tuebingen, Department II (department of hematology, oncology, rheumatology and immunology), Tuebingen
  3. University Eye Hospital Tuebingen, Department I (department of general ophthalmology)
  1. Dr Nicole Stuebiger, University Eye Hospital, Tuebingen, Schleichstrasse 12-16, 72076 Tuebingen, Germany

https://doi.org/10.1136/bjo.84.12.1432g

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    Editor,—One of the main problems in ocular Behçet's disease (BD) is severe posterior uveitis with retinal vessel occlusion and secondary ischaemic changes leading to retinal neovascularisation and to bad prognosis despite immunosuppression.

    Previously we have shown the efficacy of interferon alfa (IFNα)-2a in posterior uveitis and especially in retinal vasculitis with reopening of occluded vessels.1 Now we demonstrate the antiangiogenic effect of IFNα-2a in one BD patient with retinal neovascularisations. The IFNα-2a treatment has resulted in complete remission of the retinal neovascularisations without laser coagulation of non-perfusion areas, which would have been the standard therapy.

    CASE REPORT

    A 27 year old man with recurrent oral aphtosis, pustular skin lesions, epididymitis, arthritis (elbow, sacroiliac joint), and retinal vasculitis of the left eye was diagnosed in October 1998 as having Behçet's disease (BD), according to the criteria of …

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