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Br J Ophthalmol 84:181-185 doi:10.1136/bjo.84.2.181
  • Original Article
    • Clinical science

Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists

Table 6

Number of ocular and systemic adverse events reported during the study (withdrawn patients included)

Adverse event Latanoprost Timolol-pilocarpine
Ocular (n=39) (n=94)
Ocular discomfort 33 70
Blurred vision  2 54
Decreased visual acuity  4 18
Decreased twilight vision  1 14
Visual field changes/scotoma  4 11
Photophobia  0  9
Eyelid pain and discomfort  2  9
Conjunctival hyperaemia  7  5
Increased IOP  1  3
Punctate corneal erosions  2  0
Conjunctivitis  1  2
Other 13 12
Systemic (n=11) (n=36)
Headache  4 25
Dizziness  1  4
Influenza  4  1
Vertigo/imbalance  1  4
Nausea  0  1
Other  3  9
  • In parenthesis, n = number of patients reporting adverse events.

  • Ocular discomfort includes burning, itching, tearing, dry eye, stinging, foreign body eye sensation, and eye pain. Some events reported as serious adverse event, a total of six patients for both treatments groups. Please see text for explanation.

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