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Br J Ophthalmol 84:512-516 doi:10.1136/bjo.84.5.512
  • Original Article
    • Clinical science

3 Year simvastatin treatment and lens nuclear back scattering

Table 4

Comparison of nuclear back scattering of light in the crystalline lens between systemic treatment with simvastatin and placebo

Sources of variation Degree of freedom Mean square (GSU)2 Expected mean square Test statistic (Ff1:f2:0.95)
Treatments   1 0.3327 ς2 ε+cς2 B+bcκ2 α  0.93 (3.84)
Times   2 0.1635 ς2 ε2 +abκ2 γ 10.64 (3.00)
Patients 158 0.3582 ς2 ε+cς2 B
Int (Tr − T)   2 0.0137 ς2 ε2 +bκ2 αγ  0.89 (3.00)
Int (P − T) 316 0.0154 ς2 ε2
  • Int (Tr − T) = interaction between treatments and time points. Int (P − T) = interaction between patients and time points. κ2 = a factor corresponding to the systematic shift because the indexed fixed source; α = treatment; γ = time points. ς2 = The expected variance for the indexed random source; B = patients, ε = measurement error. a = The number of treatments = 2; b = the number of patients within a treatment = 80; c = the number of time points for each patient = 3.

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