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Br J Ophthalmol 84:591-595 doi:10.1136/bjo.84.6.591
  • Original Article
    • Clinical science

Coagulation pathways and diabetic retinopathy: abnormal modulation in a selected group of insulin dependent diabetic patients

Table 2

Clinical, laboratory, and haemocoagulative data in diabetics (in relation to diabetic retinopathy: BDR = background DR; NPDR = non-proliferative DR; PDR = proliferative DR) and in healthy controls (n = mean(SD)

No DR (n = 22) BDR (n = 21) NPDR (n = 15) PDR (n = 9) Controls (n = 50)
Sex (M/F) 9/13 5/15 2/5 6/12 19/31
Age range (years) 16–55 15–62 16–65 24–70 20–68
Mean age (years) 36.4 (10.5) 41.2 (17.3) 42.10 (12.3) 43.6 (13.1) 38.6 (12.2)
Duration of diabetes (years) 11.4 (6.9) 17.8 (5.7) 18.0 (1.2) 18.1 (7.2)
HbA1c (%) 6.1 (1.0) 6.2 (1.1) 6.3 (1.2) 6.6 (1.0)
Microalbuminuria (patients) 2 5 9
Macroalbuminuria (patients) 9
Total cholesterol (mg/dl) 180.9 (31.0) 187.5 (46.0) 192.1 (31.1) 204.2 (49.4) 189.6 (22.7)
HDL cholesterol (mg/dl) 51.4 (9.8) 47.8 (6.7) 47.2 (5.2) 46.4 (8.4) 50.4 (3.5)
Triglycerides (mg/dl) 118.8 (52.6) 131.5 (46.8) 140.1 (31.3) 165.2 (34.5) 144.6 (28.2)
FVII:Ag (% standard) 98.6 (33.1) 108.8 (30.9) 117.6 (22.8) 131.6 (21.7) 102.9 (29.8)
FVII:c (U/dl) 79.7 (18.4) 92.8 (16.9) 105.3 (10.4) 126.0 (34.3) 88.6 (15.8)
F1+2 (μg/l) 0.82 (0.46) 1.08 (0.58) 1.07 (0.43) 1.41 (0.61) 0.78 (0.24)
  • PDR v No DR, PDRv BDR, PDR vcontrols: p <0.005; PDR v NPDR: p <0.05

  • No DR v controls: p >0.05 (not significant).

  • PDR v No DR, PDRv BDR, PDR vcontrols: p <0.0001; PDR v NPDR: p <0.05

  • No DR v controls: p >0.05 (not significant).

  • PDR v No DR, PDRv controls: p <0.005; PDRv BDR, PDR vNPDR: p <0.05

  • No DR v controls: p >0.05 (not significant).

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