Table 1
Clinical course of CRVO after intravitreal TPA injection, classified from the shorter to the longer duration of symptoms before treatment
| Case no | Age (years) | Sex | Associated medical conditions | CRVO duration before TPA injection (days) | Dose of TPA | Initial visual acuity | Initial form of CRVO | Visual outcome |
| 1 | 64 | M | Hypertension, smoking, activated protein C resistance, CRVO in the second eye | 1 | 75 μg | 20/70 | non-ischaemic CRVO | 20/20, non-ischaemic CRVO |
| 2 | 60 | F | Hypercholesterolaemia, glaucoma, HRT | 2 | 100 μg | 20/40 | non-ischaemic CRVO | CF, ischaemic CRVO, PRP |
| 3 | 70 | M | Hyperlipidaemia | 4 | 75 μg | 20/30 | peripheral ischaemic area of 30 DD | 20/200, CME, unchanged ischaemic area |
| 4 | 69 | F | None | 5 | 100 μg | 20/400 | non-ischaemic CRVO with cilioretinal AO | CF, ischaemic CRVO, PRP, preretinal neovascularisation |
| 5 | 58 | M | Glaucoma | 5 | 100 μg | 20/200 | non-ischaemic CRVO with cilioretinal AO | 20/125, non-ischaemic CRVO, CME |
| 6 | 57 | M | Diabetes, stopped smoking | 5 | 75 μg | 20/40 | non-ischaemic CRVO | 20/400, ischaemic CRVO, PRP |
| 7 | 53 | M | Myocardial infarction, hyperlipidaemia, stopped smoking | 5 | 75 μg | 20/30 | non-ischaemic CRVO | 20/70, non-ischaemic CRVO, CME |
| 8 | 74 | M | Stopped smoking | 5 | 100 μg | 20/70 | non-ischaemic CRVO | |
| 9 | 37 | F | Smoking | 6 | 75 μg | 20/40 | non-ischaemic CRVO | 20/15, non-ischaemic CRVO |
| 10 | 72 | F | Hypertension, overweight, hypercholesterolaemia, | 8 | 75 μg | 20/40 | non-ischaemic CRVO | 20/25, non-ischaemic CRVO |
| 11 | 72 | F | Hypertension, overweight | 8 | 100 μg | CF | ischaemic CRVO | CF, ischaemic CRVO, PRP |
| 12 | 49 | M | Hyperlipidaemia, overweight, stopped smoking | 14 | 75 μg | 20/50 | peripheral ischaemic area of 30 DD | 20/40, unchanged ischaemic area, CME |
| 13 | 61 | M | Hypertension, myocardial infarction, stopped smoking | 15 | 75 μg | 20/160 | non-ischaemic CRVO | 20/25, non-ischaemic CRVO |
| 14 | 67 | M | Hypertension, glaucoma, myocardial infarction | 21 | 75 μg | 20/400 | peripheral ischaemic area of 20 DD | CF, ischaemic CRVO, rubeosis iridis, PRP |
| 15 | 60 | M | hypertension, hyperlipidaemia, angina pectoris, stopped smoking | 21 | 75 μg | 20/50 | non-ischaemic CRVO | 20/20; non-ischaemic CRVO |
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PRP = panretinal photocoagulation; HRT = hormone replacement therapy for postmenopausal woman; DD = disc diameters; CMO = cystoid macular oedema; AO = artery occlusion; CF = counting fingers.
