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Br J Ophthalmol 84:654-666 doi:10.1136/bjo.84.6.654
  • Perspective

Matrix metalloproteinase biology applied to vitreoretinal disorders

Table 2

Properties of tissue inhibitors of metalloproteinases (TIMPs)

TIMP-1 TIMP-2 TIMP-3 TIMP-4
Chromosome location (human) Xp11.23–11.4 17q2.3–2.5 22q12.1–13.2 unknown
 Protein (kDa) 28 21 24 22
 mRNA (kB) 0.9 3.5 (1.0) 4.5 (5.0, 2.4, 2.6, 2.8) 1.2 (1.4)
 Expression inducible mainly constitutive inducible unknown
Main form of molecule secreted secreted ECM associated secreted

  • ↵Reviewed in references 9 and 86.

  • ↵Numbers in parentheses denote possible splice variants.

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