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Br J Ophthalmol 84:750-756 doi:10.1136/bjo.84.7.750
  • Original Article
    • Clinical science

Expression of vascular endothelial growth factor in uveal melanoma and its correlation with metastasis

Table 3

Relation of tumour characteristics to metastases and VEGF

Metastasis Mean VEGF
Cell type
 Spindle 3/17 (17.6%) 2.11
 Mixed 8/21 (38.1%) 2.04
 Epithelioid 5/5 (100%) 3.8
Size
 Small 3/20 (15%) 2
 Medium 10/17 (58.8) 2.16
 Large 3/6 (50%) 3.33
Mitoses
  0–9 per 20 hpf 9/32 (28.2%) 2.29
 >10 per 20 hpf 7/11 (63.6%) 2.15
Necrosis
 Absent 9/26 (34.6%) 1.81
 Present 7/17 (41.2) 2.85
Pigmentation
 Minimal 6/21 (28.6%) 2.86
 Moderate 7/11 (63.4%) 1.67
 Marked 3/11 (27.3%) 1.91
Microvascular pattern
 Other 6/28 (21.4%) 1.93
 Loop/networks 10/14 (71.4%) 2.78
Microvascular density
 <75/mm2 1/14 (7.1%) 2
 75–150/mm2 7/13 (53.8%) 2.46
 150–225/mm2 3/4 (75.0%) 1.71
 >225/mm2 5/12 (41.7%) 4.85
  • Correlation with metastasis.

  • Correlation with VEGF.

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