Demographic and clinical data
| Case | Age | Sex | Causes of ulcer | Eye | Associated surface problems/duration of ulcers (months) | Previous surgery | Previous management for surface problems | AMT | Subsequent surgery | VA-pre | VA-post | Other ocular problems | Epithelial healing (days) | Follow up (months) | Complication |
| 1 | 69 | M | (1) HSV (2) HSV, PKP |
LE | KCS, keratouveitis, bacterial superinfection/2.8 (2) perforation/1.2 | (1) Glaucoma surgery with Baeveldt (2) PKP |
Punctal occlusion | AMT+bandage CL (2) AMT (3 layers) | (1) PKP (2) Partial tarsorrhaphy (34 days later) PKP+partial tarsorrhaphy (59 days later) |
(1)LP (2) HM |
(1) HM (2) LP |
Parkinson's disease, glaucoma, optic nerve atrophy | (1) 14 (2) 50* |
(1) 19 (2) 24 |
(2) Non-healing and perforation until repeat PKP+tarsorrhaphy |
| 2 | 81 | M | HZO, PKP | LE | 50% thinning/2.3 | PKP (2x), ECCE | Conjunctival flap, patching | AMT (3 layers) + bandage CL | — | 4/200 | 20/200 | Choroidal detachment, hypotony | 20 | 38 | — |
| 3 | 78 | M | HZO, PKP | LE | Trichiasis, 75% thinning/3.1 | PKP (2x), ECCE | Partial tarsorrhaphy | AMT (3 layers) | PKP+AMT as patch | HM | 20/50 | — | 13 | 26 | — |
| 4 | 47 | F | HZO | LE | KCS, 20% thinning/2.5 | — | — | AMT as patch | — | CF | 20/80 | AIDS | 18 | 8 | — |
| 5 | 78 | M | HZO, DM, PKP | LE | Trichiasis, KCS, 30% thinning/1.8 | PKP | Punctal occlusion, Botox ptosis, lid margin eversion | AMT | Partial tarsorrhaphy (27 days later) | HM | 20/200 | — | 74* | 26.5 | Non-healing until 47 days after tarsorrhaphy |
| 6 | 86 | F | DM | RE | 25% thinning/2.0 | ECCE, cryotherapy | — | AMT+ bandage CL | — | NLP | NLP | NVG, optic nerve atrophy | 20 | 3.7 | — |
| 7 | 51 | M | DM | RE LE | KCS, lagophthalmos, 50% thinning, both eyes/3.5 | — | Patching, punctal occlusion, Botox ptosis | AMT (2 layers) | Partial tarsorrhaphy (14 days later) | (1) 4/200 (2) 2/200 | (1) 20/200 (2) 20/300 | PDR | (1) 34*
(2) 34* |
(1) 23.3 (2) 23.3 |
Non-healing until 20 days after tarsorrhaphy |
| 8 | 65 | M | DM | LE | 40% thinning/3.6 | Glaucoma surgery with Seton | — | AMT + AMT as patch | — | HM | LP | NVG | 34 | 8 | — |
| 9 | 30 | M | DM, PKP | RE | KCS/3.2 | ECCE, PKP | Punctal occlusion | AMT+ bandage CL | — | 2/200 | 2/200 | — | 34 | 52 | — |
| 10 | 4 | M | Radiation | LE | KCS, limbal deficiency/4.2 | — | Punctal occlusion | AMT+ Lateral tarsorrhaphy | — | HM | 1/200 | Retinoblastoma | 11 | 22 | — |
| 11 | 71 | M | Radiation, PKP | RE | KCS, trichiasis, limbal deficiency, 75% thinning/3.6 | PKP (3x) | Punctal occlusion, Partial tarsorrhaphy | AMT (3 layers)+ AMT as patch | — | 20/200 | HM | Malignant lymphoma of orbit | 6 | 19 | — |
| 12 | 62 | M | Removal of Acoustic Neuroma | RE | Facial palsy, KCS 75% thinning/4.5 | — | Punctal occlusion, Botox ptosis, gold weight, bandage CL | AMT (3 layers)+AMT as patch | Partial tarsorrhaphy and removal of gold weight (7 days later) | 20/200 | 20/200 | Acoustic neuroma | 6 | 8.5 | — |
| 13 | 70 | M | PKP, DM | RE | Failed graft, limbal deficiency, sterile ulcer with infiltration/2.4 | PKP (3X) | — | AMT + Sectorial KLAL | — | HM | HM | — | 16 | 6 | — |
| 14 | 61 | F | PKP | LE | Band keratopathy, failed graft, cicatricial entropion, trichiasis, KCS/4.5 | PKP, ECCE | Punctal occlusion lid margin eversion | AMT+AMT as patch | Punctal occlusion | HM | 20/400 | Glaucoma | 16 | 6 | — |
| 15 | 86 | F | PKP | LE | Band keratopathy, failed graft/3.6 | PKP, vitrectomy scleral bucking | — | AMT + AMT as patch | — | NLP | NLP | RD, glaucoma, rheumatoid arthritis | 8 | 6 | — |
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AIDS = acquired immune deficiency syndrome; AMT = amniotic membrane transplantation; CF = counting fingers; CL = contact lens; DM = diabetes mellitus; ECCE = extracapsular cataract extraction; HM = hand movement; HSV = herpes simplex virus; HZO = herpes zoster ophthalmicus; KCS = keratoconjunctivitis sicca; KLAL = keratolimbal allograft; LP = light perception; NLP = no light perception; NVG = neovascular glaucoma; PDR = proliferative diabetic retinopathy; PKP = penetrating keratoplasty; RD = retinal detachment; VA = visual acuity.
