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Br J Ophthalmol 84:899-902 doi:10.1136/bjo.84.8.899
  • Original Article
    • Clinical science

Expression of VLA-2, VLA-3, and αv integrin receptors in uveal melanoma: association with microvascular architecture of the tumour and prognostic value

Table 3

Univariate analysis estimating the risk for developing metastases

Variable Odds ratio 95% Confidence interval p Value
Extraocular growth 10.4 1.2–90.1 0.03
Scleral infiltration 5.4 2.1–14.1 0.0006
Vascular patterns:
 Vascular networks 3.1 1.2–8 0.02
 Loops and networks 5.3 2.1–13.7 0.0005
 Loops, networks, and cross  linking 5.2 2.1–13.2 0.0004
Ciliary body involvement 3.8 1.5–9.3 0.003
Histological cell type (mixed and epithelioid) 2.5 1–5.8 0.04
Greatest tumour diameter (continuous) 1.1 1–1.2 0.01
Sex (male) 1.3 0.6–3.1 0.5
Age (>60 years) 1.9 0.8–4.4 0.1
VLA-2 (positive) 0.5 0.2–1.3 0.2
VLA-3 (<25% positive cells) 0.7 0.2–1.9 0.5
αv (<50% positive cells) 1.2 0.5–2.9 0.7

  • ↵Tumours with vascular networks (n=25) and tumours with vascular loops without networks (n =7).

  • ↵As above () plus tumours with parallel vessels with cross linking (n=8).

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