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Br J Ophthalmol 84:907-913 doi:10.1136/bjo.84.8.907
  • Original Article
    • Clinical science

Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival

Table 3

Sites of spread for 192 patients with ocular adnexal lymphoma, classified by histological type. (Column percentages in parentheses)

Site of spread Histological category of lymphoma
MZL (82 cases) LPL (44 cases) FCL (20 cases) DLCL (19 cases) H5 (21 rare variants) All (192 cases)
Local extraorbital extension 2  (2%) 3  (7%) 5  (25%) 11  (58%) 3  (14%) 24  (13%)
Temporalis fossa 0 2 (5%) 4 (15%) 7 (37%) 3 (14%) 16 (8%)
Sinuses 1 (1%) 2 (5%) 1 (4%) 6 (32%) 1 (5%) 11 (6%)
Nasopharynx 1 (1%) 1 (2%) 1 (4%) 1 (5%) 3 (14%) 7 (4%)
Intracranial 1 (1%) 1 (2%) 0 2 (11%) 3 (14%) 7 (4%)
Nodes 22 (27%) 19 (43%) 13 (50%) 4 (21%) 10 (48%) 68 (35%)
Bone marrow 3 (4%) 7 (16%) 2 (8%) 0 11 (52%) 23 (12%)
Spleen 3 (4%) 7 (16%) 2 (8%) 2 (11%) 2 (10%) 16 (8%)
Liver 4 (5%) 0 1 (4%) 1 (5%) 2 (10%) 8 (4%)
Skin 12 (15%) 7 (16%) 7 (27%) 4 (21%) 6 (29%) 36 (19%)
Salivary gland 5 (6%) 1 (2%) 2 (8%) 0 1 (5%) 9 (5%)
Lung 4 (5%) 1 (2%) 1 (4%) 2 (11%) 1 (5%) 9 (5%)
Gut 2 (2%) 3 (7%) 0 1 (5%) 1 (5%) 7 (4%)
Breast 1 (1%) 0 2 (8%) 0 0 3 (2%)
Body cavity 1 (1%) 3 (7%) 0 0 1 (5%) 5 (3%)
Kidney 1 (1%) 0 2 (8%) 1 (5%) 0 4 (2%)
Heart 1 (1%) 0 0 1 (5%) 0 2 (1%)
Muscle 1 (1%) 0 0 1 (5%) 0 2 (1%)
Bone 1 (1%) 0 0 0 1 (1%) 2 (1%)
Total 33 (40%) 25 (57%) 16 (62%) 13 (68%) 21 (100%) 108 (56%)
  • Pericardial, peritoneal and pleural cavities.

  • MZL = marginal zone lymphoma; LPL = diffuse lymphoplasmacytoid/lymphoplasmacytic lymphoma; FCL = follicle centre lymphoma; DLCL = diffuse large B cell lympoma; H5 = rare histological variants.

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