Table 3
Inducible models for retinal degenerations
| Animal (strain) | Cell layer | Degeneration time course | References | |
| Induction by light | ||||
| white fluorescent light, up to 2 hours | rat (ZUR-SIV) | ONL, RPE | immediately–24 hours after exposure | 62, 87 |
| white fluorescent light, up to 2 hours | mouse (C57BL/6 × 129Sv) | ONL | immediately–24 hours after exposure | 63, 86 |
| fluorescent light, 1 week, 2000 lux | rat (Sprague-Dawley) | ONL | full degeneration at end of exposure | 88 |
| intermittent green fluorescent light | albino rat (Lewis) | ONL, RPE | depending on stimulus onset | 92 |
| green fluorescent light, up to 24 hours | albino rat (Lewis) | ONL, RPE | starts at 6 hours after exposure | 94 |
| intraocular fibre optic light | owl monkey | ONL, RPE | 1 hour–4 weeks after exposure | 95 |
| Others | ||||
| prenatal intraperitoneal injection of MNU | mouse (CD-1 albino) | ONL, OPL, IPL | time and dose dependent | 96 |
| intraperitoneal injection of MNU | rat (Brown-Norway) | ONL | time and dose dependent | 97-99 |
| intraperitoneal injection of MNU | mouse (C57BL6) | ONL | time and dose dependent | 100 |
| insertion of iron wire into vitreous | rabbit | ONL | 24 hours–4 days after insertion | 101 |
| implantation of iron particle into vitreous | rat (Sprague-Dawley) | ONL | 1–2 days after implantation | 102 |
| intravitreal injection of l-ornithine hydrochloride | rat (Brown-Norway) | RPE, ONL | immediately–14 days after injection | 103, 121 |
| murine coronavirus | mouse (BALB/c) | ONL, RPE | immediately–32 days after inoculation | 122 |
| vitamin E deficient diet for 3 months | rat (RCS-rdy+) | ONL, RPE | immediately after diet | 123 |
| intravitreal injection of LHP | rabbit (New Zealand white) | ONL, RPE | few hours–18 days after injection | 124 |
| hypoxia, beginning on p15 | rat (Sprague-Dawley) | ONL, INL | initial degeneration at p 21 | 125 |
