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Letter to the Editor
Successful treatment of ocular invasive mould infection (fusariosis) with the new antifungal agent voriconazole
  1. ALEXANDER REIS,
  2. RAINER SUNDMACHER
  1. Eye Hospital, Heinrich-Heine-University Duesseldorf
  2. Robert-Koch-Institut Berlin
  3. Eye Hospital, University of Freiburg
  4. The Royal Veterinary and Agricultural University, Department of Pharmacology and Pathobiology, Copenhagen
  5. Eye Hospital, Heinrich-Heine-University Duesseldorf
  1. KATHRIN TINTELNOT
  1. Eye Hospital, Heinrich-Heine-University Duesseldorf
  2. Robert-Koch-Institut Berlin
  3. Eye Hospital, University of Freiburg
  4. The Royal Veterinary and Agricultural University, Department of Pharmacology and Pathobiology, Copenhagen
  5. Eye Hospital, Heinrich-Heine-University Duesseldorf
  1. HANSJÜRGEN AGOSTINI
  1. Eye Hospital, Heinrich-Heine-University Duesseldorf
  2. Robert-Koch-Institut Berlin
  3. Eye Hospital, University of Freiburg
  4. The Royal Veterinary and Agricultural University, Department of Pharmacology and Pathobiology, Copenhagen
  5. Eye Hospital, Heinrich-Heine-University Duesseldorf
  1. HENRIK ELVANG JENSEN
  1. Eye Hospital, Heinrich-Heine-University Duesseldorf
  2. Robert-Koch-Institut Berlin
  3. Eye Hospital, University of Freiburg
  4. The Royal Veterinary and Agricultural University, Department of Pharmacology and Pathobiology, Copenhagen
  5. Eye Hospital, Heinrich-Heine-University Duesseldorf
  1. CHRISTOPH ALTHAUS
  1. Eye Hospital, Heinrich-Heine-University Duesseldorf
  2. Robert-Koch-Institut Berlin
  3. Eye Hospital, University of Freiburg
  4. The Royal Veterinary and Agricultural University, Department of Pharmacology and Pathobiology, Copenhagen
  5. Eye Hospital, Heinrich-Heine-University Duesseldorf
  1. Dr Alexander Reis, Eye Hospital, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany reis{at}uni-duesseldorf.de

https://doi.org/10.1136/bjo.84.8.928d

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    Editor,—Voriconazole is a new, highly potent, triazole with broad spectrum activity against fungi, including moulds as well as fluconazole resistant Candidaspp.1 Like other azole antifungal agents it interferes with ergosterole biosynthesis. Its antifungal activity has been shown in several experimental as well as clinical studies.2-5

    CASE REPORT

    In November 1998, a 16 year old girl was transferred to the university eye hospital in Duesseldorf with a severe ulcerative hypopyon keratitis in the left eye, from which she had been suffering for 3 months after swimming in a lake in Italy. Smears, scrapings, and serology gave no hint of the aetiology. Despite intensive topical antibacterial, anti-acanthamoebal, antifungal, and antiherpetic therapy, as well as cryoapplication, her clinical situation had deteriorated continuously before admission to our hospital. As an optical rehabilitation was unlikely, owing to the severely …

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