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Br J Ophthalmol 84:1061-1063 doi:10.1136/bjo.84.9.1061
  • Scientific correspondence

Subretinal fluid levels of topical, oral, and combined administered ciprofloxacin in humans

Table 1

Subretinal fluid ciprofloxacin levels following different application modes (μg/ml)

Patient no Topical ciprofloxacin Patient no Oral ciprofloxacin Patient no Topical+oral ciprofloxacin
1 0.20 1 0.52 1 1.92
2 0.31 2 0.94 2 0.93
3 0.21 3 0.48 3 0.54
4 0.07 4 0.41 4 0.58
5 0.54 5 1.21 5 1.41
6 0.22 6 0.74 6 0.81
7 0.12 7 0.66 7 2.12
8 0.44 8 0.36 8 1.28
9 0.10 9 1.01 9 0.50
10 0.15 10 1.10 10 0.63
11 0.24 11 0.68 11 0.86
12 0.11
Mean (SEM) 0.23 (0.04) Mean (SEM) 0.74 (0.09) Mean (SEM) 1.05 (0.17)
  • Two drops of 0.3% solution every 30 minutes for 3 hours and every 60 minutes for the next 3 hours before the operation.

  • A single dose 1000 mg 6 hours before the operation.

  • A single dose 1000 mg 6 hours before the operation and two drops of 0.3% solution every 30 minutes for 3 hours and every 60 minutes for the next 3 hours before the operation.

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