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Letter to the Editor
Late complications after pterygium excision with high dose mitomycin C instillation
  1. SEIJI HAYASAKA,
  2. YOSHIO IWASA,
  3. YASUNORI NAGAKI,
  4. CHIHARU KADOI,
  5. MASAYUKI MATSUMOTO,
  6. YORIKO HAYASAKA
  1. Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan
  1. ophthal{at}ms.toyama-mpu.ac.jp

https://doi.org/10.1136/bjo.84.9.1075h

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    Editor,—To prevent recurrence of pterygia after excision, instillation of 0.04% mitomycin C has been used in Japan and northern America. However, early (less than 14 months) development of serious complications including scleral ulceration has been reported.1-3 Fujitani et alhave reported that corneal perforation developed 33 months after therapy. 1n the present study we report on late complications of mitomycin C treatment.

    CASE REPORT

    Four patients were included in this study (Table 1). All patients underwent pterygium excision and postoperative topical instillation of 0.04% mitomycin C four times a day for 2–3 weeks. The patients complained of ocular pain or irritation 18–25 years after treatment. Scleral ulceration with calcified plaque was found. After plaques were …

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