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Br J Ophthalmol 85:88-90 doi:10.1136/bjo.85.1.88
  • Scientific correspondence

Thermolabile MTHFR genotype and retinal vascular occlusive disease

Table 2

Odds ratios for retinal vascular occlusive disease and increased total plasma homocysteine (tHcy) levels conferred by TT genotype

TT Odds ratio 95% CI
Cases (n=87) 13 (14.9%) 0.84 0.37 to 1.90
 Venous (n=61) 8 (9.2%) 0.72 0.29 to 1.83
 Arterial (n=26) 5 (5.7%) 1.14 0.37 to 3.51
 versus
Controls (n=87) 15 (7.2%)
Cases with increased tHcy (n= 43) 5 (11.6%) 0.59 0.18 to 1.98
 versus
Cases with normal tHcy (n=44) 8 (18.1%)
Controls with increased tHcy (n=22) 2 (9.0%) 0.40 0.04 to 2.04
 versus
Controls with normal tHcy (n=65) 13 (20.0%)
All subjects with increased tHcy (n=65) 7 (9.2%) 0.51 0.20 to 1.26
 versus
All subjects with normal tHcy (n=109) 21 (19.2%)
  • TT = homozygous for thermolabile MTHFR genotype.

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